Determination of oxytetracycline

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Determination of oxytetracycline in biological matrix.

Oxytetracycline (OTC) has been used for years in medical field. It is a wide-spectrum antibiotic, belonging to the group of tetracyclines with bacteriostatic activity (1-4). OTC chemical name is 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro3,5,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxotetracene-2-carboxamide. OTC possesses broad antimicrobial spectrum, similar to tetracycline. The antibioti...

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Rapid and Validated Hplc Assay for the Determination of Oxytetracycline in Biological Material

A rapid, accurate, simple, and reproducible high performance liquid chromatographic (HPLC) method for the determination of oxytetracycline hydrochloride (OTC) in porcine plasma has been developed and validated. The drug and the standard were eluted from 5 μm Omni Spher (Varian) C18 column (250 mm × 4.6 mm I.D.) at room temperature. The mobile phase was composed of ACN-MeOH-(HCOO)2 (17.5:17.5:65...

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Early diagnosis of prostate cancer by citrate determination in urine with europium-oxytetracycline complex.

Normal prostate tissue contains high levels of citrate. In the presence of prostate cancer, the citrate level is diminished. In this paper we show that it is possible to use europium-oxytetracycline complex as a citrate fluorescent probe and consequently as a prostate cancer probe. We analyzed normal nude male mice urine and urine from nude male mice in which prostate cancer was induced by intr...

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Determination of oxytetracycline residues in cattle meat marketed in the Kilosa district, Tanzania.

Oxytetracycline is used to treat various diseases in cattle. However, its use may be associated with unacceptable residue levels in food. Oxytetracycline residues in tissues from indigenous cattle were determined in a cross-sectional study conducted in the Kilosa district, Tanzania, between November 2012 and April 2013. A total of 60 tissue samples, including muscle, liver and kidney, were coll...

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ژورنال

عنوان ژورنال: BUNSEKI KAGAKU

سال: 1957

ISSN: 0525-1931

DOI: 10.2116/bunsekikagaku.6.782